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Filtered Search Results
TARGETMOL CHEMICALS INC VU6012962 10MG
Also available in 1 mg 2 mg 5 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. VU6012962 is an orally bioavailable negative allosteric modulator of CNS-penetrant metabotropic glutamate receptor 7(mGlu7; IC50 347 nM). purity: 98%
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Medchemexpress LLC Regorafenib monohydrate | 1019206-88-2 | MFCD17170366 | 99.9% | 500.8 g/mol | C21H17ClF4N4O4 | 50 MG
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Regorafenib monohydrate is the monohydrate form of regorafenib, a multi-targeted receptor tyrosine kinase inhibitor used as a research reagent and analytical standard. It exhibits potent inhibition of VEGFR, PDGFR, KIT, RET, and RAF kinases and is used in preclinical assays to study antitumor and antiangiogenic activity.
- High purity (≈99.9%) suitable for analytical work.
- Monohydrate form with molecular weight 500.8 g/mol.
- Useful as an analytical standard and research reagent in kinase assays.
- Available in small, quantified laboratory packages for preclinical studies.
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eMolecules 1952360-91-6 | (Fmoc-amino)-PEG12-C2-carboxylic acid | Chem-Impex | MFCD08064302 | 839.973 | C42H65NO16 | 98.000 | OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)OCC1c2ccccc2-c2ccccc12 | 5g | 686069703
(Fmoc-amino)-PEG12-C2-carboxylic acid | Chem-Impex | 1952360-91-6 | MFCD08064302 | 839.973 | C42H65NO16 | 98.000 | OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)OCC1c2ccccc2-c2ccccc12 | 5g | 686069703
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Apexbio Technology LLC Tideglusib 865854-05-3 200mg
Tideglusib is a potent selective inhibitor of glycogen synthase kinase-3 (GSK-3 ) functioning through irreversible and ATP-noncompetitive inhibition with reported IC50 of 60 nM Mechanistically Tideglusib binds in a manner independent of ATP leading to sustained enzyme inactivation Preclinical studies utilizing animal models demonstrate Tideglusib s ability to attenuate hyperphosphorylation of Tau protein reduce amyloid plaque accumulation prevent neuronal loss and enhance cognitive performance Currently undergoing clinical investigation Tideglusib has advanced through Phase II studies for Alzheimer s disease (AD) and progressive supranuclear palsy (PSP) exploring therapeutic applicability related to its GSK-3 inhibition activity
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Medchemexpress LLC Nitrendipine | 39562-70-4 | 99.7% | 200 MG
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Nitrendipine (BAY-E-5009) is an orally active dihydropyridine calcium channel blocker, an analog of Nifedipine. It has been shown to induce apoptosis and possess antihypertensive effects. This compound can block alcohol and morphine withdrawal symptoms, reduce right ventricular hypertrophy, and mitigate pulmonary vascular changes induced by intermittent hypoxia. Furthermore, Nitrendipine exhibits anticancer effects on neuroblastoma cells.
- Orally active dihydropyridine calcium channel blocker
- Induces apoptosis
- Provides antihypertensive effects
- Blocks alcohol and morphine withdrawal symptoms
- Reduces right ventricular hypertrophy
- Mitigates pulmonary vascular changes induced by intermittent hypoxia
- Exhibits anticancer effects on neuroblastoma
- Inhibits Cav1.2 current
- Prevents behavioral signs of ethanol withdrawal
- Attenuates lipid peroxidation in the lung
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Ambeed AMBEED
5000891793 2-METHYLINDOLINE-6-CARBO 250MG
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Ambeed AMBEED
5000895018 2-O4-C-METHYLENEGUANOSIN 100MG
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Ambeed AMBEED
5000895925 2-O4-C-METHYLENEGUANOSINE 1GR
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Medchemexpress LLC Ipragliflozin L-Proline | 951382-34-6 | 99.9% | 519.58 | 200 MG
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Ipragliflozin (L-Proline) is a highly potent and selective SGLT2 inhibitor with an IC50 of 2.8 nM, showing little to no potency for SGLT1/3/4/5/6. It is intended for research use only.
- Potently and selectively inhibits human, rat, and mouse SGLT2.
- Exhibits stability against intestinal glucosidases.
- Shows good pharmacokinetic properties following oral dosing.
- Dose-dependently increases urinary glucose excretion.
- Reduces blood glucose and plasma insulin levels.
- Improves glucose intolerance.
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Medchemexpress LLC Ulixertinib (Standard) | 869886-67-9 | 99.9% | 433.33 | 200 MG
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Ulixertinib is a potent, orally active, and highly selective ATP-competitive, reversible covalent inhibitor of ERK1/2 kinases. It effectively inhibits ERK2 with an IC50 of <0.3 nM, reducing phosphorylated ERK2 (pERK) and downstream kinase RSK (pRSK) activity in A375 melanoma cells.
- Potent, orally active, and highly selective
- ATP-competitive and reversible covalent inhibitor of ERK1/2 kinases
- Inhibits ERK2 with an IC50 of <0.3 nM
- Reduces phosphorylated ERK2 (pERK) and downstream kinase RSK (pRSK) activity
- Demonstrates antiproliferative activity in various cell lines
- Investigated in clinical trials for multiple conditions, including solid tumors and various cancers
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Medchemexpress LLC Pleconaril | 153168-05-9 | 99.48% | 381.35 | 200 MG
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Pleconaril is a picornavirus capsid binding inhibitor that prevents attachment and/or virus uncoating. It has potential for use in research related to rhinoviruses and enteroviruses.
- Prevents attachment and/or virus uncoating
- For research use only
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Biotium Tyramides and Tyramide Signal Amplification Kits Fluorescence Microscopy Reactive CF Dyes Other Dyes Biotinylation Reagents TyraMax 560 580 1/EA
TyraMax Dyes are next-gen tyramide (TSA) dyes for spatial biology with colors from blue to near-IR named for their excitation/emission They are stable in amplification buffer with advantages in color selection brightness and photostability vs other TSA dyes 100X in DMSO 20 uL trial size
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Medchemexpress LLC Amino-PEG3-C2-sulfonic acid | 1817735-43-5 | 99.47% | 257.30 | 100 MG
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Amino-PEG3-C2-sulfonic acid is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs consist of two distinct ligands connected by a linker, with one targeting an E3 ubiquitin ligase and the other targeting the protein of interest. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Utilized in the synthesis of PROTACs
- Contains two distinct ligands connected by a linker
- Exploits intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
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TARGETMOL CHEMICALS INC Allethrin 200MG
Also available in 1 mL, 10 mg, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. Allethrin induces oxidative stress, apoptosis and calcium release. Allethrin, a pyrethroid insecticide is a major mosquito repellent agent. Purity 98.19%
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TARGETMOL CHEMICALS INC Abiraterone 200MG
Also available in 1 g, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 500 mg and bulk. Please contact Fisher for quotes. Abiraterone (CB-7598) (CB-7598) is an effective steroidal cytochrome P450 17alpha-hydroxylase-17, 20-lyase (CYP17) inhibitor (IC50 4 nM). Purity 99.87%
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